Mozafari, Masoud, Masayuki Shimoda, Aleksandra M. Urbanska, and Sophie Laurent. Ultrasound-targeted microbubble destruction: toward a new strategy for diabetes treatment. Drug discovery today 21, no. 4 (2016): 540-543. Ultrasound-targeted microbubble destruction is a promising technique with an immense target specific gene delivery potential deep inside the human body. The potential of this technique has recently been confirmed for diabetic patients. This technology allows the genes to transfer specifically into the inefficient pancreas using ultrasound energy without viral vector utilization. It has been speculated that this idea and the advent of modern gene therapy techniques could result in significant future advances. This schematic shows gene therapy mediated by ultrasound-targeted microbubble destruction UTMD for the treatment of diabetes.
This image captured by Peiman B Milan shows Masson’s trichrome staining of the control, DDM and HUCPVCs-DDM groups at 21 days post implantation. High collagen accumulation and deposition was observed after 21 days.
Quantum dots (QDs) with their unique optical properties have attracted widespread interest in cancer diagnosis and therapy. Due to their ability to absorb and emit light very efficiently, lead sulfide (PbS) hollow spheres with nanometer-to-micrometer dimensions having tailored structural, optical, and surface properties represent an important class of QDs that are potentially useful for early cancer detection. In this study, PbS hollow sphere QDs have been successfully synthesized using a template free and green method. This figure demonstrates typical SEM micrographs and Schematic illustration of the synthesized PbS hollow sphere QDs.
Shabafrooz, V., Mozafari, M., Köhler, G.A., Assefa, S., Vashaee, D. and Tayebi, L., 2014. The effect of hyaluronic acid on biofunctionality of gelatin–collagen intestine tissue engineering scaffolds. Journal of Biomedical Materials Research Part A, 102(9), pp.3130-3139. Four z-stack sections of a scaffold with adherent Caco-2 cells. Cells were stained with nucleic acid dye Hoechst 33342 (blue fluorescence) and the lipophilic dye Nile Red (red and yellow/green fluorescence; see text). The scaffold is also visible as a large red fluorescence section, presumably because of nonspecific binding of Nile Red. Cellular red fluorescence indicates membranes rich in polar lipids and yellow/ green fluorescence areas rich in neutral lipids (e.g., lipid droplets).
Urbanska, A.M., Karagiannis, E.D., Au, A.S., Dai, S.Y., Mozafari, M. and Prakash, S., 2016. What's Next for Gastrointestinal Disorders: No Needles?. Journal of Controlled Release, 221, pp.48-61. This image is a diagrammatic representation of local delivery of oligonucleotides to colonic tumors. Particles, which have been delivered via GI tract, including stomach, contain either DNA or siRNA and become activated at the targeted site.
Surface modification of poly (lactide-co-glycolide) nanoparticles by d-α-tocopheryl polyethylene glycol 1000 succinate as potential carrier for the delivery of drugs to the brain. The image shows that the higher stirring time may cause bigger 274 well defined spherical micro particles up to 50µm.
Milan, P. Brouki et al. Accelerated wound healing in a diabetic rat model using decellularized dermal matrix and human umbilical cord perivascular cells. Acta Biomaterialia (2016). Accelerated wound healing in a diabetic rat model using decellularized dermal matrix and human umbilical cord perivascular cells. This figure shows the angiogenesis activity of the scaffolds were detected by immunofluroscence staining for VEGFR-2 expression (red) in wound tissue are shown for different groups at the day 7 post implantation. The HUCPVCs-loaded DDM group showed a higher number of VEGFR-2-positive endothelial cells.
Development of a Cost‐Effective and Simple Protocol for Decellularization and Preservation of Human Amniotic Membrane as a Soft Tissue Replacement and Delivery System for Bone Marrow Stromal Cells. Advanced healthcare materials 4, no. 6 (2015): 918-926. IHC staining for human collagen types I, III, and IV (green) located in the basement membrane of N and D HAM samples. The cells were counterstained with DAPI (blue). The DAPI-stained epithelial cells are apparent along the apical surface of the tissues.
This figure shows TEM micrograph of the HAp nanoparticles in designed nanocomposite scaffolds with compositions based on PVA and HAp nanoparticles using colloidal HAp nanoparticles combined with freeze-drying technique by Ali Poursamar et. al for tissue engineering applications.

The Mozafari Group is a leading broad-based multidisciplinary research group of scientists with expertise in basic and applied research into different aspects of biomedical engineering. The group applies multidisciplinary strategies to gain a better quantitative/qualitative understanding of the clinical conditions, and seeks to uncover unexpected biological interactions in the human body. Please refer to the “Contact us” page for further information about how to contact, collaborate or join the group. Contact us >>